av C Bergman · 2017 — propofol, ketamin. Key words: alphaxalone, Alfaxan, anesthesia, cat, feline, pharmacokinetics, pharmacodynamics, side effects, propofol 

Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a desired target concentration in a central or effect-site compartment. Our aim was to develop a PK–PD model for propofol that can predict the bispectral index (BIS) for a broad population, suitable for TCI applications.

Pharm-95B03 Give a brief account of drug protein binding and outline its significance. Pharm-95A03 Define Phase I and Phase II reactions in drug metabolism. Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Se hela listan på drugs.com Models of propofol pharmacokinetics and pharmacodynamics developed in patients without brain pathology are widely used for target-controlled infusion (TCI) during brain tumour excision operations.

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– Raemer, D.B.; Buschman, A.;  Propofol, 3. Propofol administration & dosage, 7. Propofol Propofol: pharmacokinetics: congr, 1. Propofol pharmacology, 4. Propofol: pharmacology: congr, 1.

Anesthesiology: The Journal of the American Society of Anesthesiologists.

Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a desired target concentration in a central or effect-site compartment. Our aim was to develop a PK–PD model for propofol that can predict the bispectral index (BIS) for a broad population, suitable for TCI applications.

Curve fitting was performed using Propofol 20 mg/ml can be used for infusion undiluted or diluted. Please refer to section 6.6 for diluents and co-administration of the medicinal product. For intravenous use.

Pharmacokinetic Properties of the Nephrotoxin Orellanine in cardioprotection in an experimental model of the Takotsubo syndrome - isoflurane vs. propofol.

Ledande  av C Bergman · 2017 — propofol, ketamin.

Dyck GB, Shafer SL. Effects of age on propofol pharmacokinetics, Seminars in Anesthesia 11:2-4, 1992.. Glass PS, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D. Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: remifentanil (GI87084B). Anesth Analg 77:1031-1040, 1993 Pharmacokinetics The pharmacokinetics of propofol are well described by a three compartment linear model with compartments representing the plasma, rapidly equilibrating tissues, and slowly equilibrating tissues. Following an IV bolus dose, there is rapid equilibration between the plasma and the brain, accounting for the rapid onset of anesthesia. Despite the very long elimination half-life, blood propofol concentrations appeared to approach steady state within 20 min rather than the 4-5 half-lives normally expected. This is because for this drug, which displays multicompartment pharmacokinetics, the rate of initial rise of blood concentrations is governed primarily by the very short distribution half-life of the drug. The pharmacokinetics of propofol and alfentanil, in the absence of other drugs, have been described by several investigators and for various patient populations.
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This process occurs with a redistribution halftime in the 2-8 minute range.

Weight was found to be a significant covariate for elimination clearance, the two intercompartmental clearances, and the volumes of the central compartment, the shallow peripheral compartment, and the deep peripheral compartment; power functions with exponents smaller than 1 yielded the best results. Our clinical experiences regarding the use of propofol evaluated by the COMFORT-B in young children in the pediatric surgical intensive care unit (PSICU) have recently been published by Prins et al. 8In the current article, propofol pharmacokinetics and pharmacodynamics characterized by use of the COMFORT-B and BIS on the postoperative sleep pattern in nonventilated infants are described using population modeling, to select appropriate doses in infants and to support the safe and effective The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): an electroencephalographic and hemodynamic study in a porcine model. Egan TD (1), Kern SE, Johnson KB, Pace NL. Models of propofol pharmacokinetics and pharmacodynamics developed in patients without brain pathology are widely used for target-controlled infusion (TCI) during brain tumour excision operations.
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The pharmacokinetics of propofol were investigated in two groups of five Scottish blackface sheep undergoing surgery for the implantation of subcutaneous tissue pouches. After premedication with acepromazine and papaveretum, anaesthesia was induced with either propofol at 4 mg kg-1 intravenously (group 1) or with a mixture of propofol at 3 mg kg-1 and ketamine at 1 mg kg-1 …

After premedication with acepromazine and papaveretum, anaesthesia was induced with either propofol at 4 mg kg-1 intravenously (group 1) or with a mixture of propofol at 3 mg kg-1 and ketamine at 1 mg kg-1 intravenously (group 2). characterize propofol PK over a wide range of body weights. An allometric model using TBW as the size descriptor of volumes and clearances was superior to other size descriptors to characterize propofol PK in obese patients. Keywords: anaesthetics i.v., propofol; obesity; pharmacokinetics Accepted for publication: 17 May 2010 Keywords propofol infusion pharmacokinetics Introduction Early pharmacokinetic studies of the intra-venous anaesthetic agent propofol, administered as a single i.v.

Farmakokinetiska begrepp. Pharmacokinetics: Farmakokinetik beskriver vad kroppen gör med läkemedlet. Kvantitativ analys av processer som 

P i = P TV ×e h i where P i is the parameter value (e.g. CL and V) of the ith patient, P Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a desired target concentration in a central or effect-site compartment. Our aim was to develop a PK–PD model for propofol that can predict the bispectral index (BIS) for a broad population, suitable for TCI applications. The pharmacokinetics of propofol administered as long term infusions were determined in 12 intensive care unit patients (two female; mean age 58 yr, mean weight 66.9 kg) requiring sedation during mechanical ventilation. Patients were recruited after having been administered propofol for 24 h. Propofol Pharmacokinetics and Pharmacodynamics Modelling The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

T2 - derivation of a pharmacokinetic model. AU - Cortinez, L. I. AU - Anderson, B. J. Conclusions: Brain tumours might alter the pharmacokinetics of propofol. Caution should be exerted when using propofol.